Meningioma patients often present a loss of chromosome 22q, with inactivating neurofibromin2 (NF2, the gene coding for merlin) mutations in monosomic 22 specimens: NF2 expression level is positively and significantly correlated with PRKACA expression (R = 0.2994, p < 0.05), suggesting that both genes are downregulated in meningioma. This evidence concerns the gene PRKACA and meningioma.