Subsequently, we focused on the four genes that are differentially over-expressed in recurrent meningioma: cell division cycle protein 2 homolog (CDC2, which codes for Cyclin-dependent kinase 1, CDK1), MLF1IP coding for Centromere Protein U (CENPU), Cyclin-dependent kinases regulatory subunit 2 (CKS2), and Protein Regulator of cytokinesis 1 (PRC1). This evidence concerns the gene CENPU and meningioma.