By analysing the kinome and phosphoproteomic profiles of meningioma of different grades, it was recently shown that the A-kinase anchoring protein 12, a docking protein for PKA RII, was downregulated according to increasing malignancy grade, by comparing Grades II and III to Grade I meningiomas; this highlights AKAP12 as a prognostic marker for invasiveness and a central regulator in meningioma [46]. Here, AKAP12 is linked to meningioma.