SOX9 and neoplasm: It is well documented that SOX10 suppresses Wnt/β-catenin signaling and reduces epithelial-mesenchymal transition (EMT) migration and invasion of tumor cells, and enhances apoptosis as a tumor suppressor [45], whereas SOX9 enhances the growth of lung adenocarcinoma [46] with poor prognosis of patients with colorectal cancer [47].