MLT+Ptero exhibited significant cytotoxicity, suppressed the proliferative activity and Ki67 expression, increased TUNEL-positive cells and ROS production, cleaved PARP and caspase 3, attenuated the expression of Bcl-xL, NEDD9, and SOX9, and also activated SOX10 compared to MLT or Ptero alone in colon cancer cells. Here, NEDD9 is linked to colonic neoplasm.