In total, 16 melanoma marker genes (S100A1, ABCB5, CDH19, MIA, SLC26A2, MCAM, S100A2, S100P, MAGEA4, TFAP2C, SFRP1, SERPINA3, CSPG4, TYRP1, IL13RA2, S100A7A) were highly expressed in melanomas with activating mutations (Figure 1A,C). The gene discussed is CSPG4; the disease is melanoma.