Since the hepatic expression of miR-101-3p was markedly decreased in InsR+/− mice fed MCD (Figure 2B), we next focused on better understanding its impact on fibrogenesis promotion and HCC development by evaluating the expression of miR-101-3p putative mRNA targets, previously predicted by bioinformatic analysis and proven by experimental evidence [14] in InsR+/− HSCs compared to wt by exploiting RNAseq data. This evidence concerns the gene INSR and hepatocellular carcinoma.