Furthermore, even zonula occludens-1 (ZO-1), which has cell adhesion properties, was positively correlated to the expression of miR-101-3p in HSCs (p < 0.01; Figure S3C) and it displayed lower levels in InsR+/− HSCs compared to wt ones (p < 0.01 vs. wt HSCs; Figure S3C), supporting the fact that the down-regulation of miR-101-3p observed during IR may predispose to advanced fibrosis and exert pro-carcinogenic effects. Here, INSR is linked to fibrosis.