INSR and metabolic dysfunction-associated steatohepatitis: To confirm the potential involvement of the differentially expressed miRNAs in IR-induced liver injury and to explore their impact on hepatic fibrosis, we also analyzed the expression of those miRNAs selected by RNAseq analysis to induce NASH in livers resected from InsR+/− and control mice challenged with regular or MCD diet for 6 weeks.