AFP and cancer: Nonetheless, Li et al. [25] analyzed the data from The Cancer Genome Atlas (TCGA) and demonstrated that miR-101-1 expression was lower in cancer than in non-tumor liver tissues, and that this downregulation was also closely related to poor differentiation; high tumor, node, and metastasis (TNM) classification; poor tumor stage; positive lymph node metastasis; high alpha-fetoprotein; and poor overall survival in patients [47], assuming a great diagnostic and prognostic value of HCC [25].