NAFLD has a strong inherited component, and variants in proteins regulating hepatocellular lipid handling, including patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane bound O-acyltransferase domain-containing 7 (MBOAT7), predispose to the disease development and progression to NASH and fibrosis [4]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.