INSR and metabolic dysfunction-associated steatotic liver disease: In the multivariate generalized linear model analysis comparing wt and InsR+/− mice fed a standard or MCD diet, we found a significant negative correlation between miR-34b-3p expression and the presence of histological steatosis (beta: −2.20; CI: −3.71 to −0.66; p = 0.006), lobular inflammation (beta: −2.50; CI: −4.30 to −0.66; p =0.009), and NAS score (beta: −1.41; CI: −2.30 to −0.51; p = 0.003), suggesting that its downregulation is involved in early stages of NAFLD (Table 2).