In fact, it has been shown that sulforaphane decreases hypoxia-increased HIF-1α half-life in HCT116 colon cancer cells [49] and that capsaicin induces p53-mediated HIF-1α degradation in non-small cell lung carcinoma cells in hypoxic environment [50]. The gene discussed is HIF1A; the disease is non-small cell lung carcinoma.