PTK2 and cancer: Based on FAK overexpression and/or increased activity in cancer and its known function in multiple biological processes that play a role in the development and progression of cancers, such as crosstalk between cell and his microenvironment, cell growth, survival, adhesion, spreading, migration, invasion, angiogenesis, DNA damage repair, radioresistance, and regulation of cancer stem cells, it has been suggested that increased the expression and/or activity of FAK may have a critical role in cancer development and progression [33].