PTK2 and cholangiocarcinoma: In the TCGA database, point mutations with a single-base substitution in FAK gene, resulting in amino acid substitutions in FAK protein, are found in 6.1% of endometrial carcinoma, 3.5% of colorectal adenocarcinoma, 3.3% of melanoma, 2.7% of cholangiocarcinoma, and less frequently in other tumors, including NSCLC (Figure 3B), while no data are available in SCLC.