CD274 and small cell lung carcinoma: In SCLC specifically, the association of the PARP inhibitor olaparib and the anti-PD-L1 ICI durvalumab in a phase II trial did not meet efficacy criteria, but revealed that responses were only observed in tumors with an inflamed phenotype on tissue biopsies at baseline, which suggests that the tumor microenvironment inflammation phenotype is a potential predictive biomarker [212].