PTK2 and small cell lung carcinoma: Specifically, in SCLC cell lines, it has been shown that the inhibition of FAK activity with PF-573,228, a FAK TKI, decreased proliferation, DNA synthesis, induced cell-cycle arrest in G2-M phases, and increased apoptosis in the NCI-H82, NCI-H146, NCI-H196, and NCI-H446 SCLC cell lines [138].