AKT1 and bipolar disorder: Given the strong influence of these medications on AKT expression levels, gene-specific methylation patterns in the promoters of AKT1, 2 and 3 were analyzed in fasting skeletal muscle biopsies from 16 patients with bipolar disorders treated with an SGA (quetiapine, risperidone, olanzapine, asenapine or aripiprazole) and compared with 14 patients treated with mood stabilizers for at least 3 months.