In an acute study in male Wistar rats by Houseknecht and collaborators [105] using the HEC technique with continuous infusion of insulin (3 mU/kg/min), subcutaneous (s.c.)administration of clozapine (10 mg/kg) or olanzapine (3.2 and 10 mg/kg) substantially reduced the glucose infusion rate (GIR), an indicator of insulin resistance, and at the same time increased hepatic glucose output (HGO), a measure of both gluconeogenesis and glycogenolysis, but only in those animals receiving the higher dose. Here, INS is linked to Insulin resistance.