Furthermore, it is suggested that tumor uptake of albumin conjugated tracers will increase because of the overexpression in the tumor environment of albumin-binding proteins such as secreted protein acidic and rich in cysteine SPARC and the glycoprotein 60 (gp60) receptor, which play crucial roles in angiogenesis and capillary permeability, respectively [47]. The gene discussed is ALB; the disease is neoplasm.