TP53 and hepatocellular carcinoma: For example, coculture of human hepatoma HepG2 cells with the human hepatic stellate cell line LX2 leads to inhibition of p53 activation [83], a frequent event in HCC that makes tumor cells refractory to activate apoptosis in response to chemotherapy [84], thus protecting HepG2 cells against cisplatin-induced apoptosis [83].