For instance, using HCC cells, p53 harboring mutation p.R248Q was reported to be accompanied by resistance to doxorubicin and paclitaxel [62]; in 5-FU-resistant HCC cells, which were also cross-resistant to vincristine, doxorubicin, and paclitaxel, transfection with wild-type p53 restored apoptosis-activation in response to these drugs [63]. Here, TP53 is linked to hepatocellular carcinoma.