Seven upregulated proteins (α1B-glycoprotein, zinc-α2-glycoprotein, α2-HS-glycoprotein, VDBP, calgranulin B, A1AT, and hemopexin) and 4 downregulated proteins (prealbumin, α1-microglobulin, bikunin, and apoB/A1) in DM patients can be used as additional tests to diagnose DM [37]. The gene discussed is S100A9; the disease is diabetes mellitus.