Several classes of drugs; direct inhibitors of the renin-angiotensin system (angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers), adrenergic beta-antagonists, diuretics, sodium chloride symport inhibitors, and calcium channel blockers, are prescribed for the treatment of hypertension, though, accompanying side-effects limit their practice in medicine. Here, ACE is linked to Hypertension.