In the case of endogenous sepsis, liver cells are reported to release a large amount of HMGB-1, which binds to bacterial endotoxin (LPS); the bacterial endotoxin is transported to the cytoplasm through RAGE receptors expressed on vascular endothelial cells and macrophages, and this leads to cysteinase caspase-11-mediated cell death (pyroptosis) and results in shock, multiple organ failure, and death [36,37]. This evidence concerns the gene HMGB1 and Sepsis.