CALCA and infection: An increasing number of studies have demonstrated that presepsin (sCD14-ST) can significantly increase within 2 h and peak at 3 h after the onset of infection [148], and as a promising diagnostic biomarker for adult sepsis, many studies have shown that presepsin has advantages over PCT, CRP, and IL-6 in diagnosing the sensitivity and specificity of sepsis and assessing disease severity and prognosis [149,150,151,152].