In patients with severe sepsis and elevated IL-6, afelimomab at a dose of 1 mg/kg every 8 h was found to significantly reduce the levels of circulating TNF-α and IL-6 for 3 consecutive days; concurrently, the treatment accelerated the regression of organ dysfunction and reduced the 28-day all-cause mortality rate by 5.8% [182]. This evidence concerns the gene TNF and Sepsis.