We also showed that genes involved in spermatogenesis, such as CAPN11, UBQLN3, GGN, SPATA3, SPACA4, SPATS1, PRM1, PRM2 [25], and other important genes involved in this process, were significantly downregulated in patients with CAIS in comparison to men with normal spermatogenesis (Figure 6), even in the Case No.3, where in single sections the germ cells and spermatogenesis were presented. The gene discussed is PRM2; the disease is complete androgen insensitivity syndrome.