PROK2 and complete androgen insensitivity syndrome: In this study, we distinguished genes regulated/mediated by AR (FKBP4, LEF1, EGR1) and genes mostly associated with signal transduction of the MAPK or WNT pathway which are involved in sex differentiation (SMURF1, MAP3K15, SOX30, PROK2). We also observed significant upregulation of ID3, EGR1, JUN, FOS, MAP3K15, CASP6, and JUNB at a minimum 7-fold with p < 0.05 and downregulation of OVOL1, LEF1, SMURF1, FKBP4, PROK2, SOX30, CCDC185, DLGAP5, TACC3, BVES, PCSK2, and CATSPER3 at minimum of 4-fold with p < 0.05 in patients with CAIS (Figure 5).