Nuclear targeting PFKFB3 not only increases cell proliferation [23], our former study also showed it played a promotional role in regulating autophagy in renal cancer cells [22], and PFKFB3 deprivation reduced autophagy in rhabdomyosarcoma cells and malignant pleural mesothelioma cells [24,25]. The gene discussed is PFKFB3; the disease is malignant pleural mesothelioma.