SETD2 and neoplasm: The accumulation of NM-Ce6, with an average size of 33 nm, in tumours was studied after administration of different doses of HAase (0, 375, 750, 1500 and 3000 U) and a significant increase in the tumour uptake of NM-Ce6 (~ 2-fold) was observed with the HAase treatment with an optimal dose at 1500 U. The significant decrease of HIF-1 α after this HAase administration proved an improvement of hypoxia conditions in the tumour.