Analysis of RNAseq data for 52 normal prostate (control) and 498 prostate adenocarcinoma obtained from TCGA database, revealed that LEP, LEPR, JAK2 and STAT3 are statistically significant downregulated in prostate tumors in relation to normal (control) prostate (Figure 11). The gene discussed is STAT3; the disease is prostate adenocarcinoma.