As MMPs contribute to tumor growth, invasion, and metastasis by promoting the degradation of extracellular matrix and maintaining the tumor microenvironment [84,85], malolactomycin D suppressing the transformation activity of Ras-transformed cells by inhibiting the expression of Ras-inducible genes, such as MMP-1 and MMP-9, indicated that it was expected to be a new anticancer agent with high efficiency and low toxicity. Here, MMP9 is linked to neoplasm.