Interestingly, the chemokine (C–C motif) ligand 2 (CCL2), another cancer-related gene activated by PI3K/Akt-, -catenin-Tcf/Lef [30], has been involved in the redistribution of JAM-A in endothelial brain cells via internalization involving micropinocytosis [31]; internalized JAM-A is transiently stored in recycling endosomes and then recruited to the apical side of the endothelial cells. Here, AKT1 is linked to cancer.