BIRC5 and infection: It was previously reported by our group that overexpression of Cyan-survivin (which is 15 times greater than the expression of the endogenous survivin measured by Western blotting) resulted in a delay in the cytopathic effect (CPE) and a reduction in viral particle production caused by FCV infection that correlated with a reduced level of viral proteins [12], suggesting that survivin may have a negative effect in the early steps of the infection.