At variance, Dang et al. [17] showed that TLR3 was upregulated in cerebral organoids and human neurospheres after ZIKV MR766 infection, and TLR3 activation was associated with cell apoptosis, organoid shrinkage, and dysregulation of neurogenesis induced by ZIKV infection. The gene discussed is TLR3; the disease is Zika virus infectious disease.