CD274 and hepatocellular carcinoma: Moreover, Sia et al. focused their attention on HCC and its microenvironment (interactions among tumour cells, immune cells, and other immunomodulators present in the microenvironment) showing that 25% of HCC have markers of an inflammatory response, with high expression levels of PD-L1, markers of cytolytic activity, and fewer chromosomal aberrations [46].