Indeed, in the pivotal CheckMate 141 phase III study, nivolumab (3 mg/kg every two weeks until disease progression, unacceptable toxicity, or withdrawal of consent) demonstrated a survival benefit in patients with R/M HNSCC, with tumor progression/recurrence within 6 months of platinum therapy vs. standard of care (SoC; docetaxel, methotrexate, or cetuximab, according to investigator’s choice): mOS was 7.5 vs. 5.1 months, respectively, p = 0.01; regardless of PD-L1 expression (>1% or <1%) and regardless of tumor HPV status [8,22]. This evidence concerns the gene CD274 and neoplasm.