CD274 and head and neck squamous cell carcinoma: As presented at ASCO 2018, in a prospective study including 114 patients with metastatic HNSCC (unselected for PD-L1 status) that received ant-PD1 therapy, the development of irAEs was associated with superior ORR (30.6% vs. 12.3%), PFS, and OS (12.5 vs. 6.8 months, p = 0.003) [57].