TIMP3 and classic Hodgkin lymphoma: TIMP3 was not only expressed in the fibroblasts of 7/15 NS cHL cases and 1/11 MC cHL cases, but also in the HRS cells of 14/14 NS cHL and 9/11 MC cHL (Figure 1E,F), implicating that not only fibroblasts contribute to the accumulation of ECM via TIMP3 secretion, but also HRS cells themselves.