The Hsp60-p.Asp29Gly missense mutation (g.1512A/G on 2q32.3-q33.1 locus) was described as causing an autosomal-recessive hypomyelinating leukodystrophy that was designated MitCHAP-60 disease or HLD4, or a “complicated” SPG [12]. Here, HSPD1 is linked to hereditary spastic paraplegia.