If KSHV genomes acquire H3K27-me3 marks via KDM2B and the non-canonical PRC2 recruitment pathway, then global acquisition of H2AK119-ub would be expected to occur simultaneously with, or even prior to H3K27-me3 accumulation, and should also preclude H3K36-me2 acquisition during early infection. This evidence concerns the gene KDM2B and infection.