The N‐terminal B‐type natriuretic peptide (NT‐proBNP) was built as a contrast scale, which has been widely recognized as an important prognostic indicator of heart failure.21, 22, 23 NT‐proBNP in GRS of tertiles and quartiles showed no differentiation with ANVOA (P = 0.895; P = 0.704; Table S8). The gene discussed is NPPB; the disease is heart failure.