In the ROC analysis for the prediction of HF, the AUC for BNP was 0.673 (CI: 0.549, 0.796, P = .006), whilst the AUC for the combination of BNP and Serpina3 was 0.727 (CI: 0.613, 0.841, P < .001) (Figure S2). This evidence concerns the gene NPPB and hydrops fetalis.