Given Cdc20/APC plays critical role in governing chromatids segregation and overexpression of Cdc20 is linked to various types of cancers9, we tested the effect of CP5V in three different cancer cell lines including U2OS (osteosarcoma cell), 22Rv1 (prostate carcinoma cell) and LNCaP (prostate carcinoma cell). Here, APC is linked to osteosarcoma.