For example, the oncogene c-Myc (Myc), which is rarely mutated, but one of the most frequently amplified or afferently activated transcription factors in cancer [20], is responsible for direct transcriptional upregulation of a number of glycolytic genes and orchestrates the aforementioned biosynthetic metabolism [[21], [22], [23], [24]]. The gene discussed is MYC; the disease is cancer.