LPAR1 and familial pancreatic carcinoma: Furthermore, LPAR1_2 CRISPR KPC cells formed fewer and less invasive metastatic nodules on the peritoneum and diaphragm, confirming the LPA-LPAR1 axis as a major mediator of pancreatic cancer cell invasion and dissemination in vivo (Figures 6K, 6M, and 6N).