Our previous analyses showed differences in GLUT1, CAIX, and MCT1 expression, vascular density and 18‐fluoro‐2‐deoxyglucose (18F‐FDG) uptake between adeno‐ and squamous cell NSCLCs, supporting differences in glucose tumor metabolism among NSCLC histological subtypes.17, 18, 19 In view of the association between glucose metabolism and aggressive tumor behavior, and the worse prognosis in predominantly micropapillary and solid adenocarcinomas, we further explored glucose and glutamine metabolism‐related markers in this study within squamous cell NSCLC and subclassifications of adenocarcinomas. The gene discussed is SLC2A1; the disease is adenocarcinoma.