These results support the linkage between oncogenicmutated KRAS and EGFR signaling and aerobic glycolysis and glutamine metabolism in adenocarcinomas,38, 40, 42 and are in agreement with tumor microenvironmental characteristics: adenocarcinomas show better vascularization relative to squamous cell carcinomas, GLUT1 and MCT4 expression in a nonhypoxia‐related pattern, and a lower rate constant of cytoplasmic phosphorylation of 18F‐FDG and higher blood volume fraction on dynamic 18F‐FDG‐PET.17, 18, 19 However, a limitation is the descriptive character of this study. This evidence concerns the gene KRAS and squamous cell carcinoma.