SLC1A5 and metastatic malignant neoplasm in the lymph nodes: In a Japanese study of adenocarcinomas, SLC1A5 expression also correlated with advanced tumor stage and lymph node metastasis.28 Furthermore, a multivariate analysis demonstrated that SLC1A5 expression was an independent marker of poor overall survival for adenocarcinoma patients, while this was not observed for squamous cell NSCLCs.28 Other studies showed that SLC1A5 overexpression in the primary tumor or lymph node metastasis was found to be an independent prognostic factor for overall survival for NSCLC.25, 26 However, these studies did not distinguish adeno‐ versus squamous cell NSCLC.