Likewise, overexpressed lncRNA SPRY4 intronic transcript 1 has been demonstrated to up‐regulate E‐cadherin and down‐regulate N‐cadherin and vimentin, which would consequently impede metastasis through EMT in ovarian cancer.21 Furthermore, in other types of cancers, EMT is closely increased by many lncRNAs such as TRE, MALTA1 and HOTAIR.22 Therefore, it could be speculated that lncRNAs usually participate in the EMT of tumorigenesis. This evidence concerns the gene HOTAIR and cancer.