For example, CHD1 is a tumour suppressor in prostate cancer and oesophageal cancer 33, 34 while it seems to exert as an oncogene in breast cancer.20, 35 Interestingly, Rodrigues, LU, et al uncover that loss of CHD1 promotes aggressive prostate cancer 36; however, Zhao, D., et al revealed that knockdown of CHD1 inhibits tumour growth of PTEN‐null prostate cancer.37 In our study, CHD1 was demonstrated to be an oncogene in glioma and positively regulated by MATN1‐AS1 but negatively regulated by miR‐200b/c/429 in this disease. The gene discussed is PTEN; the disease is carcinoma of esophagus.