Recently, increasing evidence has identified that lncRNAs are dysregulated in multiple malignancies.22, 23, 24 Moreover, lncRNAs also modulated biological processes in glioma, such as proliferation, apoptosis and angiogenesis.25, 26, 27, 28 MATN1‐AS1 is a newfound lncRNA which locates in 1p35.2 and has been found downregulated in ischaemic stroke.12 In this study, we revealed that MATN1‐AS1 was highly expressed in glioma tissues and cell lines, and its upregulation was closely related to poor clinical outcomes. The gene discussed is MATN1; the disease is ischemic stroke.