miRNAs have been confirmed to be selectively packaged into exosomes, and exosomes can transfer these miRNAs to target cells or tissues to regulate gene expression.52, 53 MiR‐26a was found to target HDAC6 in myogenic differentiation of embryonic stem cells.45 More importantly, studies have demonstrated that miRNA‐26a positively influenced stroke outcome.54, 55 Here, we detected high level of miR‐26a in USC‐Exos. Here, HDAC6 is linked to stroke disorder.