Moreover, serum levels of galectin-3 [4.54 ng/mL; (range 0.85–21.57) vs 3.26 ng/mL (range 0.74–7.43); P = 0.0672] and leptin [19,542 pg/mL; (range 1041–85,500) vs 14,210 pg/mL (range 1286–39,480); P = 0.1817] were elevated in SSc patients. This evidence concerns the gene LEP and systemic sclerosis.