Comparing concentrations of each factor in particular subsets of SSc, serum fractalkine and galectin-3 levels were statistically significantly higher in dcSSc than lcSSc (3.93 ng/mL vs 2.58 ng/mL, P = 0.0018; 6.86 ng/mL vs 3.78 ng/mL, P = 0.0008, respectively). The gene discussed is CX3CL1; the disease is systemic sclerosis.