In pediatric CD, rates of mucosal healing after 1 year of anti-TNF range from 39% to 63%.24, 25 Rates of mucosal healing in adults with CD receiving optimized anti-TNF dosing regimens range from 27% to 40%5, 26 further indicating a larger than expected subset of anti-TNF responders in both pediatric and adult-onset CD. The gene discussed is TNF; the disease is Cowden disease.