PTEN and breast carcinoma: In addition, our laboratory has identified that miR‐214‐3p was significantly upregulated in bone specimens from breast cancer patients with osteolytic bone metastasis.51 We showed that miR‐214‐3p could directly regulate the protein expression TRAF3 rather than phosphatase and tensin homolog (PTEN),24 the previously verified miR‐214‐3p target in osteoclasts,52 to promote osteoclast function in the development of breast cancer osteolytic metastasis.