HFE and hyperinsulinemic hypoglycemia, familial, 4: In contrast to HfeRunx2Cre(+) and HfeLysMCre(+) mutant mice, HfeAlfpCre(+) mutant mice develop systemic iron overload characterized by increased iron levels in the blood and the liver to an extent similar to that in mice with global Hfe‐deficiency (Fig. 3A, B).10 However, no increased iron deposition was observed in either the trabeculas or in the marrow of long bones from HfeAlfpCre(+) mutant mice (Fig. 3B).