Furthermore, after analysis the relationship between ATF3 and obesity in human GEO DataSet Browser (https://www.ncbi.nlm.nih.gov/sites/GDSbrowser/), we characterize that the gene expression of ATF3 was lower in human liver (Fig. 1a)18, adipose tissue (Fig. 1b)19 and muscle (Fig. 1c)20 specimens of obese than in the lean ones, but the ATF3 expression did not differ in the blood monocytes from normal weight, mildly obese and morbidly obese subjects (Fig. 1d)21. The gene discussed is ATF3; the disease is obesity due to melanocortin 4 receptor deficiency.