RHOA and breast cancer: One study found that Wnt5a could also enhance macrophage-induced invasiveness of MCF7 cells in vitro.45 Furthermore, another study found that forced expression of Wnt5a enhanced activation of RhoA in 21PT and 21NT breast-cancer-cell lines, but only increased cellular motility in 21NT cells.46 As noted in the present study, MCF7 cells lack expression of ROR1, suggesting that some of the effects of Wnt5a on cell invasiveness may be independent of ROR1.