PTH and bone fracture: It is known that osteoclastic inhibitors such as bisphosphonates have some analgesic effect [45] and inhibition of bone resorption using RANK ligand inhibitors (e.g. denosumab [46]) or promoting bone formation with parathyroid hormone (1–34) [47] can reduce pain from bone metastases and from osteoporotic vertebral fractures in patients.