BGLAP and osteoporosis: Warfarin inhibits the vitamin-K dependent y-carboxylation of osteocalcin, leading to osteoporosis, through two ways, directly and indirectly: (1) Directly by inhibiting gamma-carboxylation of osteocalcin and (2) indirectly because patients on Warfarin are recommended to take diet low in vitamin-k (Figure 1).