Sera obtained from 63 patients with GBS or Miller Fisher syndrome (MFS) and 60 control subjects were examined for both HEV-IgM and HEV-IgG. Of the 63 patients, 3 were positive for both HEV-IgM and elevated hepatic enzymes: 2 had GBS, and one had MFS. No control subjects were positive for HEV-IgM. Our study demonstrated that 4.8% of patients with GBS or MFS from our institution had associated acute HEV infection. There were no clinical differences between GBS with HEV infection and other GBS cases. Here, CD40LG is linked to Guillain-Barre syndrome.