Nonetheless, our observed effect of IL-6 on the integrity of the outer BRB support the continued evaluation of the inhibition of combinations of soluble mediators of vascular permeability, including IL-6 using enhanced in vitro and in vivo experimental systems with a view to clinical translation for sight-threatening ME associated with diabetic retinopathy, RVO, and uveitis. This evidence concerns the gene IL6 and uveitis.