The HFF-iMSCs that differentiated from the HFF-iPSCs expressed typical MSC markers, such as CD105 and Vimentin, and were devoid of the pluripotency-associated markers OCT4 and NANOG; subsequently, they did not result in tumor formation, as also observed in our earlier study.15 However, to ensure patient safety, long-term studies need to be conducted to evaluate the probability of tumor formation. This evidence concerns the gene ENG and neoplasm.