CLN5 and pancreatitis: The paracrine function of the BMPs could be adjusted by the level of its extracellular antagonists, noggin, chordin, and sclerostin.140 The evidence from a study in pancreatitis cells suggested that BMPs may antagonize the dampening effect of noggin on microtubule-associated protein 1 light chain 3 (MAP1LC3)-II levels and subsequently increase the expression levels of Beclin-1 and lysosomal-associated membrane protein 2 (Lamp2).