Moreover, we also reported that acetaminophen is the most frequent causative drug ingredient in various cold medicines and that cold medicine-related SJS/TEN with SOC, including acetaminophen-related SJS/TEN with SOC, was significantly associated with HLA-A*02:06 and HLA-B*44:03 in Japanese individuals6. The gene discussed is HLA-A; the disease is toxic epidermal necrolysis.