In summary, acetaminophen-related SJS/TEN with SOC was not associated with HLA-class II (HLA-DRB1, DQB1), but we found an association with HLA-B*13:01 and HLA- C*14:03 in addition to HLA-A*02:06 and HLA-B*44:03, which have been described previously. Here, HLA-B is linked to toxic epidermal necrolysis.