Examples are PTBP1 which inhibits cell growth in breast cancer cell lines [76], Tra2β, a target of transcription factor and oncogene ETS-1 that is upregulated in breast cancer and is associated with cancer cell survival [77], SRSF3 that upon inhibition decreased breast cancer cell proliferation [78], the loss of PRMT5 or WDR77 resulting in AS and loss of proliferative genes [79] and HNRNPC which is highly expressed in breast tumors and of which knockdown results in double strand breaks and reduced proliferation [80]. The gene discussed is TRA2B; the disease is breast cancer.