Unlike their WT counterparts, ERO1α-KO tumors displayed little to no growth over a 24–72 h culture period (Figure 4F), and colony formation was reduced by as much as 50% (Figure 4D and 4E), suggesting that ERO1α deletion significantly reduces the replicative capacity of pancreatic cancer cells. The gene discussed is ERO1A; the disease is familial pancreatic carcinoma.