To investigate this mechanism further, we found that bAP15 could effectively suppress cell growth in the p53 null and mutant ovarian cancer cell lines SKOV3 (loss-of function TP53, nonsense mutation), MESOV (R282, hot spot mutation), and ES2 (S241F, missense mutation), respectively (Figure 4B, 4E). This evidence concerns the gene TP53 and ovarian cancer.