In a study of 972 cases from the European-American-Asian Pheochromocytoma and Paraganglioma Registry without mutations in the common PPGL genes, 58 had mutations in less commonly mutated genes (SDHA, TMEM127, SDHAF2) including 8 cases of PCC with MAX mutations. This evidence concerns the gene TMEM127 and adrenal gland pheochromocytoma.